Renee N Donahue Selected Research

Brachyury protein (Brachyury)

1/2021	Phase I study of a multitargeted recombinant Ad5 PSA/MUC-1/brachyury-based immunotherapy vaccine in patients with metastatic castration-resistant prostate cancer (mCRPC).
1/2021	Randomized, Double-Blind, Placebo-Controlled Phase II Study of Yeast-Brachyury Vaccine (GI-6301) in Combination with Standard-of-Care Radiotherapy in Locally Advanced, Unresectable Chordoma.
1/2021	Phase 1 open-label trial of intravenous administration of MVA-BN-brachyury-TRICOM vaccine in patients with advanced cancer.
1/2020	A Phase I Trial Using a Multitargeted Recombinant Adenovirus 5 (CEA/MUC1/Brachyury)-Based Immunotherapy Vaccine Regimen in Patients with Advanced Cancer.
1/2020	Improving the Odds in Advanced Breast Cancer With Combination Immunotherapy: Stepwise Addition of Vaccine, Immune Checkpoint Inhibitor, Chemotherapy, and HDAC Inhibitor in Advanced Stage Breast Cancer.
1/2020	Phase I Trial of a Modified Vaccinia Ankara Priming Vaccine Followed by a Fowlpox Virus Boosting Vaccine Modified to Express Brachyury and Costimulatory Molecules in Advanced Solid Tumors.
11/2017	Phase I Study of a Poxviral TRICOM-Based Vaccine Directed Against the Transcription Factor Brachyury.
11/2015	Phase I Trial of a Yeast-Based Therapeutic Cancer Vaccine (GI-6301) Targeting the Transcription Factor Brachyury.

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Renee N Donahue Research Topics

Disease

48	Neoplasms (Cancer) 01/2022 - 08/2008
9	Prostatic Neoplasms (Prostate Cancer) 04/2022 - 10/2014
9	Carcinoma (Carcinomatosis) 01/2020 - 10/2009
6	Ovarian Neoplasms (Ovarian Cancer) 02/2012 - 06/2009
5	Neoplasm Metastasis (Metastasis) 01/2021 - 10/2016
4	Colorectal Neoplasms (Colorectal Cancer) 11/2022 - 08/2008
4	Chordoma 01/2021 - 11/2015
4	Vaccinia 01/2020 - 05/2014
4	Breast Neoplasms (Breast Cancer) 01/2020 - 11/2014
4	Necrosis 01/2019 - 10/2010
3	Human Influenza (Influenza) 01/2021 - 05/2016
3	COVID-19 01/2021 - 10/2020
2	Infections 01/2021 - 10/2020
2	Fatigue 01/2021 - 01/2017
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2020 - 08/2008
2	Thymoma (Thymic Carcinoma) 10/2019 - 01/2019
2	Myositis (Idiopathic Inflammatory Myopathies) 01/2019 - 01/2017
2	Communicable Diseases (Infectious Diseases) 05/2016 - 01/2016
2	Carcinogenesis 11/2014 - 07/2011
2	Autoimmune Diseases (Autoimmune Disease) 05/2011 - 01/2011
1	Overweight 04/2022
1	Sarcoma (Soft Tissue Sarcoma) 01/2021
1	Mastodynia 01/2021
1	Papilloma (Papillomatosis) 01/2021
1	Lymphopenia (Lymphocytopenia) 11/2020
1	medullary Thyroid cancer 01/2020
1	Mouth Neoplasms (Oral Cancer) 01/2020
1	Thyroid Neoplasms (Thyroid Cancer) 01/2020
1	Disease Progression 10/2019

Drug/Important Bio-Agent (IBA)

17	VaccinesIBA 11/2022 - 05/2014
10	AntigensIBA 01/2021 - 01/2012
10	Opioid Analgesics (Opioids)IBA 02/2012 - 06/2009
9	avelumabIBA 11/2022 - 05/2016
9	methionine-enkephalin receptorIBA 02/2012 - 08/2008
9	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 02/2012 - 06/2009
8	Brachyury protein (Brachyury)IBA 01/2021 - 11/2015
6	Cancer VaccinesIBA 01/2020 - 01/2012
5	Transcription Factors (Transcription Factor)IBA 01/2021 - 11/2015
5	PROSTVACIBA 01/2021 - 01/2016
5	Immunoglobulin G (IgG)IBA 12/2020 - 01/2017
5	Proteins (Proteins, Gene)FDA Link 12/2020 - 02/2012
5	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 10/2010
5	Biological ProductsIBA 01/2016 - 06/2009
4	Immune Checkpoint InhibitorsIBA 01/2022 - 01/2019
4	B7-H1 AntigenIBA 10/2019 - 01/2018
4	Monoclonal AntibodiesIBA 01/2019 - 05/2016
4	EnkephalinsIBA 05/2011 - 06/2009
3	smallpox and monkeypox vaccine modified vaccinia ankara-bavarian nordicIBA 01/2021 - 08/2019
3	Prostate-Specific Antigen (Semenogelase)IBA 01/2021 - 08/2014
3	CytokinesIBA 01/2021 - 01/2019
3	Neoplasm Antigens (Tumor Antigens)IBA 01/2020 - 11/2014
3	Docetaxel (Taxotere)FDA Link 10/2016 - 11/2015
2	Bevacizumab (Avastin)FDA Link 11/2022 - 01/2015
2	Testosterone (Sustanon)FDA Link 04/2022 - 01/2021
2	enzalutamideIBA 01/2021 - 10/2014
2	AndrogensIBA 01/2021 - 10/2014
2	Transforming Growth Factor beta (TGF-beta)IBA 01/2021 - 01/2018
2	LigandsIBA 12/2020 - 01/2018
2	Histone Deacetylase InhibitorsIBA 01/2020 - 01/2018
2	entinostat (MS 275)IBA 01/2020 - 01/2018
2	B7 AntigensIBA 08/2019 - 11/2017
2	Peptides (Polypeptides)IBA 05/2016 - 10/2009
2	cabozantinibIBA 01/2015 - 11/2014
2	Sorafenib (BAY 43-9006)FDA Link 01/2015 - 11/2014
2	Tyrosine Kinase InhibitorsIBA 01/2015 - 11/2014
2	Sunitinib (Sutent)FDA Link 01/2015 - 11/2014
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2015 - 11/2014
2	Opioid Receptors (Opioid Receptor)IBA 09/2011 - 07/2011
2	Naltrexone (ReVia)FDA LinkGeneric 08/2011 - 07/2011
2	Opioid Peptides (Opioid Peptide)IBA 07/2011 - 01/2011
1	Metformin (Glucophage)FDA LinkGeneric 04/2022
1	bicalutamide (Casodex)FDA LinkGeneric 04/2022
1	Antiviral Agents (Antivirals)IBA 01/2021
1	SARS-CoV-2 spike proteinIBA 01/2021
1	SteroidsIBA 01/2021
1	Transforming Growth Factors (Transforming Growth Factor)IBA 12/2020
1	Dexamethasone (Maxidex)FDA LinkGeneric 11/2020
1	GlucocorticoidsIBA 11/2020
1	Prednisone (Sone)FDA LinkGeneric 11/2020
1	Adrenal Cortex Hormones (Corticosteroids)IBA 11/2020
1	Methylprednisolone FDA LinkGeneric 11/2020
1	Interleukin-15 (Interleukin 15)IBA 01/2020
1	Ado-Trastuzumab EmtansineIBA 01/2020
1	InterferonsIBA 01/2020
1	IodineIBA 01/2020
1	Immunoconjugates (Immunoconjugate)IBA 01/2020
1	Immune Checkpoint ProteinsIBA 01/2020
1	ALT-803IBA 01/2020
1	AntibodiesIBA 10/2019
1	Histones (Histone)IBA 01/2019
1	ChemokinesIBA 01/2019

Therapy/Procedure

21	Therapeutics 01/2022 - 07/2011
15	Immunotherapy 11/2022 - 01/2012
6	Drug Therapy (Chemotherapy) 01/2021 - 10/2014
5	Castration 01/2021 - 10/2014
2	Aftercare (After-Treatment) 01/2021 - 01/2012
2	Radiotherapy 01/2021 - 01/2012
1	Intravenous Administration 01/2021
1	Prostatectomy (Retropubic Prostatectomy) 01/2020
1	Duration of Therapy 01/2019